Resting State Blood Flow and Glucose Metabolism in Psychiatric Disorders

摘要: Over the last 20 years, SPECT and PET, along with CT MRI have been main methodologies used in studies investigating psychiatric disorders. The structural alterations patients’ brains found by are usually quite subtle, while those nuclear imaging modalities (PET SPECT) more pronounced. Partly for this reason, latter methods led to discoveries a wide range of In 90s, region interest (ROI) method provided only sketchy results due low spatial resolution imaging, but rapid progression analytic statistical 2000s had detailed accurate determinations differences regional cerebral blood flow (rCBF) glucose metabolic ratios (rGMR) between patients comparison subjects. On other hand, whereas an improved understanding etiology disorders has significant progress multiple research areas, PET measuring rCBF/rGMR distribution at rest come face some limitations elucidation disease pathophysiology. Accordingly, resting using SPECT/PET tended focus on certain kinds clinical information, such as symptomatology treatment. This review summarizes history studies, provides comprehensive survey including schizophrenia, major depressive disorder, bipolar disorder obsessivecompulsive disorder.