The Oncopig Cancer Model as a Complementary Tool for Phenotypic Drug Discovery.

摘要: The screening of potential therapeutic compounds using phenotypic drug discovery (PDD) is being embraced once again by researchers and pharmaceutical companies as an approach to enhance the development new effective therapeutics. Before genomics molecular biology era consecutive emergence targeted-drug approaches, PDD was most common platform used for discovery. PDD, also known screening, consists in either vitro cellular or vivo animal models identify resulting a desirable change. Using this approach, biological targets are not taken into consideration. Suitable crucial continued validation drugs, displaying promising results cell-based small model screenings often fail clinical trials. Indeed, mainly result differential anatomy, physiology, metabolism, immunology, genetics between humans currently pre-clinical models. In contrast, pigs more predictive treatment outcomes than rodents. addition, provide ideal study cancer due their similarities with at anatomical, physiological, metabolic, genetic levels. Here we mini-review on reemergence development, highlighting porcine improving testing. We present precision medicine based genetically defined swine developed date biomedical