NMO Spectrum Disorders

摘要: Neuromyelitis optica spectrum disorders (NMOSD) represent a rare subset of chronic-inflammatory diseases the central nervous system. Despite heterogeneities in disease activity, there is higher degree disability accumulation NMOSD patients compared to MS patients. According revised diagnostic criteria, recommendation was made abandon term NMO and summarize these conditions as NMOSD. Clinical presentation most cases optic neuritis transverse myelitis but nevertheless, can affect parts system (e. g. brainstem hypothalamus). Originally characterized AQP4-antibody-dependent disease, it has recently been discussed whether with presence antibodies against myelin oligodendrocyte glycoprotein (MOG) belong family Due severity often devastating relapses, systematic therapy necessary. Usually, immunosuppressants or monoclonal anti-inflammatory properties are used. Recently, four substances entered clinical testing for treatment