An evaluation of nerve repair with nerve allografts in normal and immunologically tolerant rats

摘要: ✓ Schwann cells survive longer in allografts of ganglia that contain minor, rather than major and transplantation antigens. The authors have investigated whether a nerve allograft with minor antigens would be superior to one incompatibilities aiding the repair injured nerve. A segment host peroneal was removed from rats replaced contained either or results showed normal rats, fibers could functionally regenerate through (that is, grow reinnervate muscle) 2 cm but not 4 length, irrespective contained. Host could, however, 4-cm if hosts were rendered immunologically tolerant donors. Furthermore, when sensitized lymphoid injected into bearing functional allografts, cell...