Integrin Regulation by RhoA in Thymocytes
作者： Susina Vielkind , Maighread Gallagher-Gambarelli , Manuel Gomez , Heather J. Hinton , Doreen A. Cantrell
DOI: 10.4049/JIMMUNOL.175.1.350
关键词:
摘要: The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival proliferation of progenitors thymus. To explore mechanisms used by RhoA to control thymocyte biology, role this GTPase regulation integrin-mediated adhesion was examined. data show that activation sufficient stimulate β 1 2 murine thymocytes. also needed integrin vivo as loss function impaired ability thymocytes adhere extracellular matrix VCAM-1 prevented induced GTPases Rac-1 Rap1A vivo. regulated activity integrins motility present study it seen critical migration chemokines vitro. Thus, a regulating during development.
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