Is the Gut the Major Source of Virus in Early Simian Immunodeficiency Virus Infection
作者： Matthew D. H. Lay , Janka Petravic , Shari N. Gordon , Jessica Engram , Guido Silvestri
DOI: 10.1128/JVI.00552-09
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摘要: The acute phases of human immunodeficiency virus (HIV) and simian (SIV) infection are characterized by rapid profound depletion CD4 + T cells from the guts infected individuals. large number in gut (a fraction which activated express HIV/SIV coreceptor CCR5), high level these cells, temporal coincidence this T-cell with peak plasma suggest that intestinal mucosa may be major source driving viral load. Here, we used data on proportions lamina propria rectums SIV-infected rhesus macaques (which progress to AIDS) sooty mangabeys do not progress) show both species, mucosal site its maximum loss rate often observed several days before load, few remaining rectum time In contrast, bronchoalveolar lavage specimens lymph nodes coincides virus. Analysis kinetics suggests that, mangabeys, a highly susceptible population for but SIV infection.
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