Targeted Delivery of IL-12 Adjuvants Immunotherapy by Oncolytic Viruses.
作者： Gabriella Campadelli-Fiume , Valerio Leoni , Andrea Vannini
DOI: 10.1007/978-3-030-55617-4_4
关键词:
摘要: The great hopes raised by the discovery of the immunoregulatory cytokine interleukin 12 (IL-12) as an anticancer agent were marred during early clinical experimentation because of severe adverse effects, which prompted a search for alternative formulations and routes of administration. Onco-immunotherapeutic viruses (OIVs) are wild-type or genetically engineered viruses that exert antitumor activity by causing death of the tumor cells they infect and by overcoming a variety of immunosuppressive mechanisms put in place by the …
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