A device for the application of cyclic twist and extension on perfused vascular segments.

摘要: Cyclic strain is known to influence many aspects of vascular cell biology, including macromolecular biosynthesis, proliferation, and morphology. The simulation the cyclic associated with vasculature in situ has been carried out mostly using devices that manipulated flat membranes on which cells choice are cultured. purpose this work was create an apparatus wherein strains consistent those found native blood vessels could be applied intact three-dimensional (tubular) specimens perfused ex vivo. protocols our may any combination axial stretch twist. Concurrently, perfusion flow shear stress controlled as desired. Vessel diameter, intraluminal pressure, volume flow, regional measured stored line. To illustrate application device, we present hemodynamic kinematic data collected from a human saphenous vein segment under steady-flow conditions while subjected