Contribution of Pre Kindling Affective State to Hemispheric Differences in the Effects on Anxiety of Basolateral Amygdala Kindling

摘要: The most commonly agreed upon forms of affective psychopathology accompanying seizure disorders in humans are depression and anxiety.1,2 A variety factors impact on affect human epileptics, complicating determination the contribution epileptic pathophysiology to psychopathology. Factors include family history, medication, psychosocial premorbid psychiatric condition1. Limbic kindling has been proposed as a model complex partial disorder with secondary generalization.1,3, 4, 5 Kindling limbic foci produces lasting changes animal behavior, including anxiety like behavior (ALB)1,6, 7, 8, 9 cognition.10 ALB produced by consistent idea that seizures change behavior. Nevertheless, nature behavioral is also complicated number clinically relevant factors.