Local organ hypersensitivity to autogenous antigens

摘要: Abstract 1.1. An allergic pneumonitis was obtained in the rabbit by using various autogenous materials as allergens. 2.2. The allergens used were: (1) partly hydrolyzed serum; (2) saline extracts of skin and homologous liver; (3) an excretory product, urine. A complementary study doen with exogenous 3.3. local sensitization lung achieved a single intrapulmonary injection allergen under investigation. After suitable time interval, shock same given intravenously developed sensitized lung. 4.4. characterized alveolar lesions (congestion, edema) vascular (endothelial reaction, endarterial, periarterial edema, infiltration eosinophilic cells small large mononuclears). 5.5. immunological mechanism involved, factors granting antigenicity to substance these experiments possible events capable leading release similar man are discussed. 6.6. These suggest that partial hydrolysis proteins, tissue destruction liberation endocellular material, reabsorption product can, certain conditions, give rise provoke pathological changes previously tissue.