EXPERIMENTAL DISSEMINATED ENCEPHALOPATHY IN THE MONKEY

摘要: It has recently been shown that injection of suspensions or extracts brain tissue may produce an experimental type encephalopathy bearing certain similarities to forms observed in the human being. In 1925 Koritschoner and Schweinburg,1and 1932 Hurst,2obtained paralysis rabbits after injections tissue. However, these investigators were unable demonstrate pathologic changes nervous system affected animals. After experiments, Rivers, Sprunt Berry3and Rivers Schwentker,4by repeated intramuscular aqueous emulsions alcohol-ether sterile normal rabbit brains, produced monkeys a "encephalomyelitis" accompanied by destruction myelin. Signs disseminated lesions central became manifest had continued for several months. The consisted areas demyelination scattered throughout system. These perivascular contained variety