Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis.

摘要: In the treatment of acute maxillary sinusitis, azithromycin offers an advantage over phenoxymethylpenicillin in that a complete course requires drug administration once daily for only three days. this double-blind, parallel-group, multicenter study, 438 patients with radiographically verified sinusitis were randomly assigned to receive either 500 mg days (221 patients) or 1.3 g times ten (217 patients). Nasal secretion, tenderness and pain, nasal obstruction, general malaise, hyposmia, assessed at start study on 4, 11, 25 treatment. After 11 58% group cured versus 51% penicillin group; after cure rate was 79% 76%, respectively. When both improvement considered, corresponding figures 97% (azithromycin) 95% (penicillin); they 92% 88%, Adverse events, predominantly gastrointestinal, occurred 73 (33%) azithromycin-treated 87 (40.1%) those treated penicillin. No difference efficacy found between two drugs adverse effects comparable. The short duration significant phenoxymethylpenicillin.