Prognostic Significance of Peripheral T-Cell Subsets in Laryngeal Squamous Cell Carcinoma.

摘要: Objectives The role of the immune system in head and neck squamous cell carcinoma is controversial. aim our study was to analyze full blood counts distribution T subsets patients affected by laryngeal cancer (LSCC) their association with clinical variables survival. Study design Retrospective study. Methods We analyzed levels platelets, lymphocytes, neutrophils, as well CD4+, CD8+, CD3+ T-cell subpopulations cytofluorometry LSCC patients. A cohort healthy used control group. disease-specific survival (DSS) considered outcome. Results Sixty-five 48 controls were enrolled. In patients, neutrophils higher than group (P < .0001). neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) both treated for recurrent disease, CD8+/CD3+ increased (P = .02), while CD4+/CD8+ .03) CD4+/CD3+ .04) ratios lower. lymph node metastases, leukocytes .03), .04), CD4+ .0098) all higher. Among Stages III-IV low lymphocyte leukocyte count associated worse DSS. Conclusion Our data demonstrate that NLR PLR are significantly LSCC. Lower CD3+/CD8+ related disease a level nodal metastasis. Level Evidence 4.