Evidence of Th2 polarization of the sentinel lymph node (SLN) in melanoma
作者： Travis E Grotz , James W Jakub , Aaron S Mansfield , Rachel Goldenstein , Elizabeth Ann L Enninga
DOI: 10.1080/2162402X.2015.1026504
关键词:
摘要: Melanoma has a propensity for lymphatogenous metastasis. Improved understanding of the sentinel lymph node (SLN) immunological environment may improve outcomes. The immune phenotype fresh melanoma SLNs (n = 13) were compared to control nodes using flow cytometry. RNA was isolated from CD4+ T cells SLN and assessed Th1/Th2 gene expression pathways qRT-PCR. In addition, VEGF between primary 6) benign nevi immunohistochemistry. had fewer CD8+ controls (9.2% vs. 19.5%, p 0.0005). within appeared have an exhausted demonstrated by increased PD-1 mRNA (2.2% 0.8%, 0.004) five-fold increase in CTLA-4 expression. also contained number CD14 (22.7% 7.7%, 0.009) CD68 (9.3% 2.7%, 0.001) macrophages, CD20 B (31.1% 20.7%, 0.008), suggesting...
elsevier.com
sci-hub.se 参考文章(30)
Silvia Sebastiani, Paola Allavena, Cristina Albanesi, Francesca Nasorri, Giancarlo Bianchi, Claudia Traidl, Silvano Sozzani, Giampiero Girolomoni, Andrea Cavani, Chemokine Receptor Expression and Function in CD4+T Lymphocytes with Regulatory Activity The Journal of Immunology. ,vol. 166, pp. 996- 1002 ,(2001) , 10.4049/JIMMUNOL.166.2.996
Duan-Ren Wen, Dave SB Hoon, Cindy Chang, Alistair J. Cochran, Variations in lymphokine generation by individual lymph nodes draining human malignant tumors. Cancer Immunology, Immunotherapy. ,vol. 30, pp. 277- 282 ,(1989) , 10.1007/BF01744894
Alistair J. Cochran, Rong-Rong Huang, Jonathan Lee, Eijun Itakura, Stanley P. L. Leong, Richard Essner, Tumour-induced immune modulation of sentinel lymph nodes. Nature Reviews Immunology. ,vol. 6, pp. 659- 670 ,(2006) , 10.1038/NRI1919
James W. Jakub, Douglas S. Reintgen, Steven Shivers, Solange Pendas, Regional node dissection for melanoma: techniques and indication. Surgical Oncology Clinics of North America. ,vol. 16, pp. 247- 261 ,(2007) , 10.1016/J.SOC.2006.10.012
S Biswas, A randomised trial evaluating bevacizumab as adjuvant therapy following resection of AJCC stage IIB, IIC and III cutaneous melanoma: an update. Ecancermedicalscience. ,vol. 2, pp. 108- 108 ,(2009) , 10.3332/ECANCER.2008.108
Fade Aziz Mahmoud, Nilo I. Rivera, The role of C-reactive protein as a prognostic indicator in advanced cancer Current Oncology Reports. ,vol. 4, pp. 250- 255 ,(2002) , 10.1007/S11912-002-0023-1
Mojgan Ahmadzadeh, Laura A. Johnson, Bianca Heemskerk, John R. Wunderlich, Mark E. Dudley, Donald E. White, Steven A. Rosenberg, Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood. ,vol. 114, pp. 1537- 1544 ,(2009) , 10.1182/BLOOD-2008-12-195792
Rebecca J Critchley-Thorne, Ning Yan, Serban Nacu, Jeffrey Weber, Susan P Holmes, Peter P Lee, Down-regulation of the interferon signaling pathway in T lymphocytes from patients with metastatic melanoma. PLOS Medicine. ,vol. 4, ,(2007) , 10.1371/JOURNAL.PMED.0040176
Yu Kato, Hiroaki Yagi, Motonobu Nakamura, Tasuku Honjo, Taku Okazaki, Yoshiki Tokura, Ryosuke Hino, Kenji Kabashima, Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma† Cancer. ,vol. 116, pp. 1757- 1766 ,(2010) , 10.1002/CNCR.24899
Kimberly A. Varker, Jennifer E. Biber, Cheryl Kefauver, Rhonda Jensen, Amy Lehman, Donn Young, Haifeng Wu, Gregory B. Lesinski, Kari Kendra, Helen X. Chen, Michael J. Walker, William E. Carson III, A Randomized Phase 2 Trial of Bevacizumab with or without Daily Low-Dose Interferon Alfa-2b in Metastatic Malignant Melanoma Annals of Surgical Oncology. ,vol. 14, pp. 2367- 2376 ,(2007) , 10.1245/S10434-007-9389-5