Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1

摘要: The study was conducted to determine the effect of physical activity on DNA methylation and predict consequence this concerning gene expression breast cancer survival. Blood samples, collected from 12 patients who participated in a randomized clinical trial exercise, were examined for exercise-related changes using microarray. Tumor samples 348 analyzed with qRT-PCR qMSP identified microarray analysis. Cox regression models developed survival outcomes association methylation. After 6 months moderate-intensity aerobic (P < 5 × 10−5) peripheral blood leukocytes detected 43 genes panel 14 495. Based list, we overall tumors found three whose reduced after exercise favorably survival, i.e., higher associated better Of genes, L3MBTL1 putative tumor suppressor known function repress chromatin transcription, which is activated mainly germline stem cells. Further analyses features among indicated that high low grade hormone receptor–positive tumors, as well risk disease recurrence death. In conclusion, suggests increasing diagnosis may affect epigenetic regulation have favorable impacts patients.