Effects of Chronic Ethanol Exposure on Cardiac Receptor-Adenylyl Cyclase Coupling: Studies in Cultured Embryonic Chick Myocytes and Ethanol Fed Rats

摘要: Ethanol effects in the brain appear to be mediated at least part by an alteration receptor-effector coupling via guanine nucleotide-binding regulatory proteins (G proteins). To test hypothesis that a similar pathway participates cardiotoxic of ethanol, we assessed chronic ethanol on two commonly used experimental models: embryonic chick myocytes culture and ventricular myocardium from chronically fed rats. had no effect either function or quantity G as effector-stimulated adenylyl cyclase activity levels ADP-ribosylation substrates. In contrast, was significantly altered liver ethanol-fed These results suggest our cardiac models is insensitive may species organ specific.