Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats.
作者： F Mannaa , HH Ahmed , SF Estefan , HA Sharaf , EF Eskander
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摘要: The aim of this work was to investigate the protective role baker's yeast Saccharomyces cerevisiae against hepatotoxic effect drug flutamide that is widely used for treatment metastatic prostate adenocarcinoma. Administration adult male rats in a dose 100 mg/kg b.w. daily 15 days resulted serious hepatic injury. Highly significant increase each serum ALT, ALP, bilirubin, bile acids and cholesterol level, relative control group, observed. Also, highly glutathione-S-transferase isoforms: alpha-GST pi-GST TNF-alpha NO levels recorded. Moreover, decrease glutathione peroxidase superoxide dismutase activities In addition, authors noticed testosterone with concomitant acid phosphatase activity. Prophylactic 4.8 days, followed by combination (100 b.w.) (4.8 other marked improvement rat's liver function, whereas retained values parallel those recorded flutamide-treated rats. Histological examination tissues showed caused hydropic degeneration, necrotic areas Kupffer cells. central vein congested blood signs apoptosis appeared hepatocytes form fragmentation nuclei blebbing cytoplasm. On hand, treated both flutamide, cords were more regularly arranged, degeneration or less pronounced some binucleated. postulate one powerful antioxidative components S. effectively participated attenuation oxidative stress metabolites, promoting regeneration new meanwhile could restore function beyond normal status.
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