Neuroprotection by Dietary Isoflavones and Their Role in Cerebral Ischemia

摘要: Abstract Dietary isoflavones derived from soybeans and other legumes have long been part of the Asian diet are considered a safe, healthy protein source. More recently, estrogenic nature has explored for postmenopausal symptoms in women with equivocal results. However, beneficial effects dietary brain received new attention recognition that these compounds can be neuroprotective experimental cerebral ischemia models neurodegenerative diseases, such as Alzheimer’s disease. Several overlapping mechanisms likely underlie protective mechanisms, including transcriptional activation by estrogen receptors multiple antioxidant on mitochondria. These generalized support all members neurovascular unit may provide both prophylactic acute neuroprotection. Human studies role soy cardiovascular health, but properties humans yet to elucidated.