Effects of a polysaccharide nanogel-crosslinked membrane on wound healing.

摘要: Introduction Wound-dressing materials that promote wound healing while protecting wounds from infections are advantageous for clinical applications. Hence, we developed a cholesterol-bearing pullulan (CHP) nanogel stimulated healing; however, it was mechanically weak and difficult to handle. Thus, the purpose of this study examine precisely effects reinforced nanogel-crosslinked (NanoClik) membrane on healing. Materials Methods NanoClik prepared by mixing thiol-terminated polyethylene glycol solution an acryloyl group-modified CHP solution. A thin silicone sheet membrane, which combined with NanoClik, prepared. The NanoClick membranes both positive negative control (collagen alone, respectively) were tested in vivo using dorsal skin defect rat model. rate extent compared between groups after 7 14 days implantation. Results In NanoClik group, area significantly reduced neoepithelialization promoted, observed other groups. In addition, extension accumulation collagen fibers evident group. Conclusion The is strong candidate use as effective safe wound-dressing material. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.