Changes in Circulating Procalcitonin Versus C-Reactive Protein in Predicting Evolution of Infectious Disease in Febrile, Critically Ill Patients

摘要: Objective Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis in the critically ill, it remains unclear how changes CRP PCT compare predicting evolution of: infectious disease, invasiveness severity (e.g. development of septic shock, organ failure non-survival) response treatment. The current study attempts clarify these aspects. Methods In 72 ill patients with new onset fever, were measured on Day 0, 1, 2 7 after inclusion, clinical courses documented over a week follow up 28. Infection was microbiologically defined, while shock defined as infection plus shock. sequential assessment (SOFA) score assessed. Results From peak at 0–2 7, decreased when (bloodstream) (Day 0–2) resolved increased complications such or 3–7) supervened. bloodstream Increased unchanged SOFA scores best predicted by increases PCT, turn, predictive 28-day outcome. Conclusion data, obtained during ICU-acquired fever infections, suggest that may be favoured judging antibiotic however, better indicate risk complications, infection, mortality, therefore might help deciding safe discontinuation antibiotics. analysis thus interpreting literature design future studies guiding therapy ICU.