Gastrointestinal Stromal Tumors and Leiomyosarcomas in the Colon

摘要: Gastrointestinal stromal tumors (GISTs), mesenchymal largely specific for the gastrointestinal tract, have been well defined in stomach and small intestine, but not extensively documented or contrasted with true smooth muscle colon. This study was undertaken to determine clinicopathologic features of GISTs colon, excluding rectum, compare them leiomyosarcomas (LMSs) same location. A total 37 colonic seven LMSs from files Armed Forces Institute Pathology Haartman University Helsinki were analyzed. The occurred predominantly adults older than 50 years age (median, 67 yrs), most histologically malignant; four benign (< = 1 cm) incidentally detected, 10 others had minimal mitotic activity (five fewer mitoses per high-power fields). typically transmural frequent intraluminal outward bulging components. Histologically, they usually showed a spindle cell pattern (92%), whereas 8% epithelioid. Most (19 25) positive CD117 (KIT) CD34 (16 27); six coexpressed alpha-smooth actin CD117; none desmin S-100 protein. C-kit mutations exon 11 seen 5 (36%) 14 GISTs. None patients incidental recurrence, 2 larger cm died disease liver metastasis. Nearly all whose tumor more five fields disease; half evidence intraluminally bulging, polypoid masses that histologic likeness differentiated cells. They men two women median 61 years. high-grade actin, desmin, both. All negative lacked c-kit mutations. Five disease, long-term survival, despite high activity. These results show KIT-positive are common these groups differences warrant their separation.