Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.
作者： Toshiyuki Nakayama
关键词: University hospital 、 Clinical risk factor 、 Gastrointestinal tract 、 Surgical pathology 、 Leiomyoma 、 Immunohistochemistry 、 Stromal cell 、 Pathology 、 Biology 、 Mesenchymal stem cell
摘要: AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose this study was to investigate role Ets-1 in growth differentiation GISTs. METHODS: Twenty-eight GISTs, nine six schwannomas were examined by immunohistochemical staining method for study. Specimens selected surgical pathology archival tissues at Nagasaki University Hospital. RESULTS: protein expressed cytoplasm cells all these tumors. Immunohistochemical revealed that 27 (96.4 %), (66.7 %), five (83.3 %) positive Ets-1. expression statistically different between (P < 0.005). However, there no correlation clinical risk categories. CONCLUSION: plays an important schwannomas.
sci-hub.st 参考文章(32)
Helen E. Remotti, Frank Aldenborg, Jeanne M. Meis-Kindblom, Lars Gunnar Kindblom, Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. American Journal of Pathology. ,vol. 152, pp. 1259- 1269 ,(1998)
S. Yamashita, T. Nakayama, J. A. Fagin, S. Naito, I. Sekine, M. Nakashima, A. Ohtsuru, M. Ito, Expression of the Ets-1 proto-oncogene in human gastric carcinoma: correlation with tumor invasion. American Journal of Pathology. ,vol. 149, pp. 1931- 1939 ,(1996)
John N. Brady, Anne Gégonne, Jürgen Dittmer, Scott D. Gitlin, Jacques Ghysdael, Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1. Journal of Biological Chemistry. ,vol. 269, pp. 21428- 21434 ,(1994) , 10.1016/S0021-9258(17)31821-5
Shinji Naito, Shunichi Shimizu, Shigeto Maeda, Jianwei Wang, Richard Paul, James A. Fagin, Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. American Journal of Physiology-cell Physiology. ,vol. 274, ,(1998) , 10.1152/AJPCELL.1998.274.2.C472
L F Fleischman, L Holtzclaw, J T Russell, G Mavrothalassitis, R J Fisher, ets-1 in Astrocytes: Expression and Transmitter-Evoked Phosphorylation Molecular and Cellular Biology. ,vol. 15, pp. 925- 931 ,(1995) , 10.1128/MCB.15.2.925
Boudewijn E. C. Plaat, Harry Hollema, Willemina M. Molenaar, Gerben H. Torn Broers, Justin Pijpe, Mirjam F. Mastik, Harald J. Hoekstra, Eva van den Berg, Rik J. Scheper, Winette T. A. van der Graaf, Soft Tissue Leiomyosarcomas and Malignant Gastrointestinal Stromal Tumors: Differences in Clinical Outcome and Expression of Multidrug Resistance Proteins Journal of Clinical Oncology. ,vol. 18, pp. 3211- 3220 ,(2000) , 10.1200/JCO.2000.18.18.3211
Mahendra Ranchod, Richard L. Kempson, Smooth muscle tumors of the gastrointestinal tract and retroperitoneum.A pathologic analysis of 100 cases Cancer. ,vol. 39, pp. 255- 262 ,(1977) , 10.1002/1097-0142(197701)39:1<255::AID-CNCR2820390139>3.0.CO;2-H
Markku Miettinen, Martti Virolainen, Maarit-Sarlomo-Rikala, Gastrointestinal stromal tumors--value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas The American Journal of Surgical Pathology. ,vol. 19, pp. 207- 216 ,(1995) , 10.1097/00000478-199502000-00009
Markku Miettinen, Maarit Sarlomo-Rikala, Leslie H. Sobin, Jerzy Lasota, Gastrointestinal Stromal Tumors and Leiomyosarcomas in the Colon The American Journal of Surgical Pathology. ,vol. 24, pp. 1339- 1352 ,(2000) , 10.1097/00000478-200010000-00003
D. Leprince, A. Gegonne, J. Coll, C. de Taisne, A. Schneeberger, C. Lagrou, D. Stehelin, A putative second cell-derived oncogene of the avian leukaemia retrovirus E26 Nature. ,vol. 306, pp. 395- 397 ,(1983) , 10.1038/306395A0