Constitutional 1p36 deletion in a child with neuroblastoma.
作者： G M Brodeur , J A Biegel , B S Emanuel , E H Zackai , H N Marshall
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摘要: We describe a child with dysmorphic features, as well developmental and growth delay, who developed neuroblastoma at 5 mo of age. Cytogenetic analysis blood lymphocytes revealed an interstitial deletion 1p36.1-->1p36.2, which was apparent only high-resolution banding. Molecular collection polymorphic DNA probes for 1p confirmed involving subbands 1p36. Deletions this region are common finding in cells from patients advanced stages disease. Therefore, these results (a) suggest that constitutional predisposed the patient to development (b) support localization tumor-suppressor locus
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