Identification of RBPMS as a smooth muscle master splicing regulator via association of its gene with super-enhancers
作者： Erick Eidy , Nakagaki Silva
DOI: 10.17863/CAM.44730
关键词:
摘要: Abstract Alternative splicing (AS) programs are primarily controlled by regulatory RNA binding proteins (RBPs). It has been proposed that a small number of master regulators might control cell-specific networks and these RBPs could be identified proximity their genes to transcriptional super-enhancers. Using this approach we RBPMS as critical regulator in differentiated vascular smooth muscle cells (SMCs). is highly down-regulated during phenotypic switching SMCs from contractile motile proliferative phenotype responsible for 20% the AS changes transition. directly regulates numerous components actin cytoskeleton focal adhesion machineries whose activity SMC function both phenotypes. also other splicing, post-transcriptional transcription including key factor Myocardin, thereby matching many criteria SMCs.
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