IgE‐mediated hypersensitivity reactions to methylprednisolone
作者： A. Aranda , C. Mayorga , A. Ariza , I. Doña , N. Blanca-Lopez
DOI: 10.1111/J.1398-9995.2010.02386.X
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摘要: To cite this article: Aranda A, Mayorga C, Ariza Dona I, Blanca-Lopez N, Canto G, Blanca M, Torres MJ. IgE-mediated hypersensitivity reactions to methylprednisolone. Allergy 2010; 65: 1376–1380. Abstract Background: Allergic systemically administered corticosteroids seem be infrequent considering their extensive use. The aim of the study was evaluate IgE response in patients with immediate allergic methylprednisolone (MP). Methods: Four subjects who developed after MP administration and ten controls good tolerance were evaluated. Skin prick intradermal testing done using MP, hydrocortisone (HC), dexamethasone (DX). If negative, a drug provocation test (DPT) confirm diagnosis assess cross-reactivity. vitro evaluated by basophil activation (BAT) ImmunoCAP. Results: Three diagnosed presence positive skin reading two one testing, patient negative DPT. All four had HC DX. BAT for just those tests, all being Two also ImmunoCAP MP. Conclusions: This confirms existence that some are mediated specific antibodies. useful diagnosis.
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