摘要: Abstract Branching morphogenesis generates epithelial trees which facilitate gas exchange, filtering, as well secretion processes with their large surface to volume ratio. In this review, we focus on the developmental mechanisms that control early stages of lung branching morphogenesis. Lung involves stereotypic, recurrent definition new branch points, subsequent budding, and tube elongation. We discuss current models experimental evidence for each these steps. Finally, role mesenchyme in determining organ-specific shape.
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