The biomechanical basis of biased epithelial tube elongation in lung and kidney development
作者： Odyssé Michos , Odyssé Michos , Dagmar Iber , Dagmar Iber , Roman Vetter
DOI: 10.1242/DEV.194209
关键词:
摘要: During lung development, epithelial branches expand preferentially in a longitudinal direction. This bias outgrowth has been linked to cell shape and the division plane. How this arises is unknown. Here, we show that biased occurs independent of surrounding mesenchyme, preferential turnover extracellular matrix at bud tips FGF signalling. There also no evidence for actin-rich filopodia tips. Rather, find tubes be collapsed during early kidney observe fluid flow narrow tubes. By simulating measured inside segmented tubes, shear stress levels on apical surface are sufficient explain reported outgrowth. We use cell-based vertex model confirm forces, unlike constricting can give rise both observed shapes tube elongation. conclude may more general driver elongation beyond its established role angiogenesis. article an associated 'The people behind papers' interview.
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