Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis.
作者： Uduak Z. George , Kishore K. Bokka , David Warburton , Sharon R. Lubkin
DOI: 10.1016/J.MOD.2015.07.003
关键词:
摘要: Branching in the embryonic lung is controlled by a variety of morphogens. Mechanics also believed to play significant role branching. The relative roles and interactions these two broad factors are challenging determine. We considered three hypotheses for explaining why tracheal occlusion triples branching with no overall increase size. Both based on blocking exit secretions. (H1) Increased lumen pressure stretches tissues; stretch receptors at shoulders growing tips local rate (H2) Blocking secretions blocks advective transport morphogens, leading (H2a) increased concentration morphogens or (H2b) flux specific locations. constructed analyzed computational models tissue solute 3D geometry. Observed stresses were predominantly locations unrelated subsequent branch locations, suggesting that not mechanism enhancement Morphogen mesenchyme occlusion, consistent previously reported results. epithelial surface completely changed its distribution pattern when trachea was occluded, tripling number which it elevated. Our results hypothesis outflow secretions, higher high-flux tips, turn large
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