Merkel Cell Polyomavirus: A Causal Factor in Merkel Cell Carcinoma

摘要: The RNA viruses hepatitis C virus and human T-cell lymphotropic type I (or leukaemia 1), the DNA B virus, high-risk papillomaviruses, herpes virus-8 (Kaposi’s sarcoma-associated virus) Epstein Barr are acknowledged as carcinogenic to humans. Human polyomaviruses have oncogenic potentials in cell cultures animal models, but their role cancer remains controversial. In 2008, a new polyomavirus member discovered Merkel carcinoma tissue was concordantly named (MCPyV). Subsequent epidemiologic studies shown that viral is present approximately 80% of carcinomas investigated MCPyV positive higher load than non-malignant tissues. addition, patients antibody levels controls. Moreover, genome seems monoclonally integrated primary tumour metastatic cells, expresses truncated version major oncoprotein, large T-antigen. This C-terminal T-antigen retains its DnaJ retinoblastoma binding domains, which necessary for transformation cells vitro, lacks helicase activity so it cannot sustain replication. These observations suggest can contribute pathogenesis may therefore add list viruses. Here we information on biology with special focus MCPyV, review carcinoma, discuss molecular mechanisms by this induce cancer.