Dietary arginine influences Rous sarcoma growth in a major histocompatibility B complex progressor genotype.

摘要: L-Arginine (L-Arg) can serve as a substrate for the production of reactive nitrogen intermediates. One these metabolites, nitric oxide, has been shown to possess significant antitumor properties in vitro. To investigate importance this system vivo, we have examined dietary L-Arg host tumor interaction chicken. Since chickens are incapable de novo synthesis, concentration amino acid is readily controlled by diet. Line UNH 105 New Hampshire having major histocompatibility complex genotype, B24/B24, were used study vivo effects on Rous sarcoma growth. After 5 weeks standard diet, 119 chicks fed either basal (0.92% L-Arg) diet or high arginine (2.40% week later, wing-web inoculated with subgroup A virus. Tumor growth was monitored weekly 12 after inoculation. Plasma levels and body weights from birds each treatment analyzed. Neither weight gains nor latent period development affected However, plasma significantly different between treatments (basal, 0.245 +/- 0.01 mumol/ml; high, 0.738 0.03 mumol/ml). In addition, mean size scores (P less than 0.05) lower over time The results suggest that excess amount required reduces load.