Developing translational research infrastructure and capabilities associated with cancer clinical trials.

摘要: The integration of molecular information in clinical decision making is becoming a reality. These changes are shaping the way research conducted, and as reality sets in, challenges conducting, managing organising multi-disciplinary become apparent. Clinical trials provide platform to conduct translational (TR) within context high quality data accrual. Integrating TR objectives allows execution pivotal studies that evidence for biomarker-driven treatment strategies, targeting early drug development homogeneous well defined patient population, supports companion diagnostics provides an opportunity deepening our understanding cancer biology mechanisms action. To achieve these goals trial, developing infrastructure capabilities (TRIC) plays critical catalytic role translating preclinical into successful development. TRIC represents technical platform, dedicated resources access expertise promoting standards, logistical operational support unified streamlined procedures under appropriate governance framework. promotes multiple disciplines including biobanking, laboratory analysis, data, informatics, statistical analysis dissemination results which all required projects scientific progress. Such supporting absolutely essential order promote robust research, avoid duplication coordinate resources. Lack such infrastructure, we would argue, one reason limited effect practice beyond trials.