From genomic landscapes to personalized cancer management-is there a roadmap?
作者： Charles Swanton , Carlos Caldas , None
DOI: 10.1111/J.1749-6632.2010.05776.X
关键词:
摘要: Despite rapid progress in annotating the human genome, biomarker discovery has been limited, part, due to restricted adoption of analysis clinical trials. In this short review we present a roadmap drive field personalized cancer management and patient stratification. We suggest that improved understanding disease biology drug response advance trial design would enable novel biomarkers be identified prospectively evaluated during early phase trials; there will also value banked material from completed trials identify validate biomarkers. Such requires standardized tissue collection protocols, bioinformatics strategies integrated with functional genomics analysis, next generation sequencing technologies. argue failure adopt these methods rapidly into increase late stage attrition, waste resources, risk harm within unselected cohorts.
harvard.edu
core.ac.uk 
sci-hub.se 参考文章(49)
W. L. Lingle, S. L. Barrett, V. C. Negron, A. B. D'Assoro, K. Boeneman, W. Liu, C. M. Whitehead, C. Reynolds, J. L. Salisbury, Centrosome amplification drives chromosomal instability in breast tumor development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 1978- 1983 ,(2002) , 10.1073/PNAS.032479999
Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia Sequist, Neal I. Lindeman, Carly Murphy, Sara Akhavanfard, Beow Y. Yeap, Yun Xiao, Marzia Capelletti, A. John Iafrate, Charles Lee, James G. Christensen, Jeffrey A. Engelman, Pasi A. Jänne, Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Cancer Cell. ,vol. 17, pp. 77- 88 ,(2010) , 10.1016/J.CCR.2009.11.022
Elizabeth Iorns, Nicholas C. Turner, Richard Elliott, Nelofer Syed, Ornella Garrone, Milena Gasco, Andrew N.J. Tutt, Tim Crook, Christopher J. Lord, Alan Ashworth, Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer Cancer Cell. ,vol. 13, pp. 91- 104 ,(2008) , 10.1016/J.CCR.2008.01.001
Rocio Sotillo, Juan-Manuel Schvartzman, Nicholas D. Socci, Robert Benezra, Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal Nature. ,vol. 464, pp. 436- 440 ,(2010) , 10.1038/NATURE08803
Christopher J. Lord, Nicholas Turner, Alan Ashworth, Utilizing RNA interference to enhance cancer drug discovery Nature Reviews Drug Discovery. ,vol. 6, pp. 556- 568 ,(2007) , 10.1038/NRD2355
Alan Ashworth, A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair Journal of Clinical Oncology. ,vol. 26, pp. 3785- 3790 ,(2008) , 10.1200/JCO.2008.16.0812
Sohrab P Shah, Ryan D Morin, Jaswinder Khattra, Leah Prentice, Trevor Pugh, Angela Burleigh, Allen Delaney, Karen Gelmon, Ryan Guliany, Janine Senz, Christian Steidl, Robert A Holt, Steven Jones, Mark Sun, Gillian Leung, Richard Moore, Tesa Severson, Greg A Taylor, Andrew E Teschendorff, Kane Tse, Gulisa Turashvili, Richard Varhol, René L Warren, Peter Watson, Yongjun Zhao, Carlos Caldas, David Huntsman, Martin Hirst, Marco A Marra, Samuel Aparicio, None, Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature. ,vol. 461, pp. 809- 813 ,(2009) , 10.1038/NATURE08489
Fulvia Farabegoli, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Domenico Marrano, Nicola Baldini, Clone heterogeneity in diploid and aneuploid breast carcinomas as detected by FISH Cytometry. ,vol. 46, pp. 50- 56 ,(2001) , 10.1002/1097-0320(20010215)46:1<50::AID-CYTO1037>3.0.CO;2-T
L. D. Wood, D. W. Parsons, S. Jones, J. Lin, T. Sjoblom, R. J. Leary, D. Shen, S. M. Boca, T. Barber, J. Ptak, N. Silliman, S. Szabo, Z. Dezso, V. Ustyanksky, T. Nikolskaya, Y. Nikolsky, R. Karchin, P. A. Wilson, J. S. Kaminker, Z. Zhang, R. Croshaw, J. Willis, D. Dawson, M. Shipitsin, J. K. V. Willson, S. Sukumar, K. Polyak, B. H. Park, C. L. Pethiyagoda, P. V. K. Pant, D. G. Ballinger, A. B. Sparks, J. Hartigan, D. R. Smith, E. Suh, N. Papadopoulos, P. Buckhaults, S. D. Markowitz, G. Parmigiani, K. W. Kinzler, V. E. Velculescu, B. Vogelstein, Genomic landscapes of human breast and colorectal cancers Science. ,vol. 318, pp. 1108- 1113 ,(2008) , 10.1126/SCIENCE.1145720
J. Downward, Y. Yarden, E. Mayes, G. Scrace, N. Totty, P. Stockwell, A. Ullrich, J. Schlessinger, M. D. Waterfield, Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences Nature. ,vol. 307, pp. 521- 527 ,(1984) , 10.1038/307521A0