Carcinoma of unknown primary - rare but ripe for help from genomics?

作者: Penelope Schofield , Lisa Guccione , Linda Mileshkin , David Bowtell

DOI:

关键词:

摘要: The treatment of most cancer patients is based on first determining where the arose anatomically - lung, breast, prostate and so on. For a group with disseminated disease, this crucial starting point missing. Carcinoma or adenocarcinoma unknown primary diagnosis made likely site origin cannot be detected. Here we describe use molecular genetic tests to improve both identification for carcinoma possible novel options presence specific mutations. We outline Solving Unknown Primary Cancer study, which aimed at utility testing in primary.

参考文章(28)
Charles Swanton, Carlos Caldas, None, From genomic landscapes to personalized cancer management-is there a roadmap? Annals of the New York Academy of Sciences. ,vol. 1210, pp. 34- 44 ,(2010) , 10.1111/J.1749-6632.2010.05776.X
Richard W Tothill, Jason Li, Linda Mileshkin, Ken Doig, Terence Siganakis, Prue Cowin, Andrew Fellowes, Timothy Semple, Stephen Fox, Keith Byron, Adam Kowalczyk, David Thomas, Penelope Schofield, David D Bowtell, None, Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary. The Journal of Pathology. ,vol. 231, pp. 413- 423 ,(2013) , 10.1002/PATH.4251
George Pentheroudakis, Vassilios Golfinopoulos, Nicholas Pavlidis, Switching benchmarks in cancer of unknown primary: from autopsy to microarray. European Journal of Cancer. ,vol. 43, pp. 2026- 2036 ,(2007) , 10.1016/J.EJCA.2007.06.023
Wendy A. Cooper, Sandra O’Toole, Michael Boyer, Lisa Horvath, Annabelle Mahar, What's new in non-small cell lung cancer for pathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements. Pathology. ,vol. 43, pp. 103- 115 ,(2011) , 10.1097/PAT.0B013E328342629D
Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram, Pasi A. Jänne, Olivier Kocher, Matthew Meyerson, Bruce E. Johnson, Michael J. Eck, Daniel G. Tenen, Balázs Halmos, EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib The New England Journal of Medicine. ,vol. 352, pp. 786- 792 ,(2005) , 10.1056/NEJMOA044238
Anirudh Prahallad, Chong Sun, Sidong Huang, Federica Di Nicolantonio, Ramon Salazar, Davide Zecchin, Roderick L. Beijersbergen, Alberto Bardelli, René Bernards, Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR Nature. ,vol. 483, pp. 100- 103 ,(2012) , 10.1038/NATURE10868
Janet E. Dancey, Philippe L. Bedard, Nicole Onetto, Thomas J. Hudson, The Genetic Basis for Cancer Treatment Decisions Cell. ,vol. 148, pp. 409- 420 ,(2012) , 10.1016/J.CELL.2012.01.014
Jeffrey S. Ross, Jorge Torres-Mora, Nikhil Wagle, Timothy A. Jennings, David M. Jones, Biomarker-Based Prediction of Response to Therapy for Colorectal Cancer: Current Perspective American Journal of Clinical Pathology. ,vol. 134, pp. 478- 490 ,(2010) , 10.1309/AJCP2Y8KTDPOAORH
Kerby A. Shedden, Jeremy M.G. Taylor, Thomas J. Giordano, Rork Kuick, David E. Misek, Gad Rennert, Donald R. Schwartz, Stephen B. Gruber, Craig Logsdon, Diane Simeone, Sharon L.R. Kardia, Joel K. Greenson, Kathleen R. Cho, David G. Beer, Eric R. Fearon, Samir Hanash, Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. American Journal of Pathology. ,vol. 163, pp. 1985- 1995 ,(2003) , 10.1016/S0002-9440(10)63557-2
Funda Meric-Bernstam, Gordon B. Mills, Overcoming implementation challenges of personalized cancer therapy Nature Reviews Clinical Oncology. ,vol. 9, pp. 542- 548 ,(2012) , 10.1038/NRCLINONC.2012.127