The Genetic Basis for Cancer Treatment Decisions
作者： Janet E. Dancey , Philippe L. Bedard , Nicole Onetto , Thomas J. Hudson
DOI: 10.1016/J.CELL.2012.01.014
关键词: Biology 、 Cancer 、 Conceptual framework 、 MEDLINE 、 Clinical trial 、 Knowledge management 、 Precision medicine 、 Repertoire 、 Personalized medicine 、 Cancer treatment
摘要: Personalized cancer medicine is based on increased knowledge of the mutation repertoire and availability agents that target altered genes or pathways. Given advances in genetics, technology, therapeutics development, timing right to develop a clinical trial research framework move future decisions from heuristic evidence-based decisions. Although challenges integrating genomic testing into treatment decision making are wide-ranging complex, there scientific ethical imperative realize benefits personalized medicine, given overwhelming burden unprecedented opportunities for advancements outcomes patients.
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Iwanka Kozarewa, Daniel J. Turner, 96-Plex Molecular Barcoding for the Illumina Genome Analyzer Methods of Molecular Biology. ,vol. 733, pp. 279- 298 ,(2011) , 10.1007/978-1-61779-089-8_20
John Eid, Adrian Fehr, Jeremy Gray, Khai Luong, John Lyle, Geoff Otto, Paul Peluso, David Rank, Primo Baybayan, Brad Bettman, Arkadiusz Bibillo, Keith Bjornson, Bidhan Chaudhuri, Frederick Christians, Ronald Cicero, Sonya Clark, Ravindra Dalal, Alex Dewinter, John Dixon, Mathieu Foquet, Alfred Gaertner, Paul Hardenbol, Cheryl Heiner, Kevin Hester, David Holden, Gregory Kearns, Xiangxu Kong, Ronald Kuse, Yves Lacroix, Steven Lin, Paul Lundquist, Congcong Ma, Patrick Marks, Mark Maxham, Devon Murphy, Insil Park, Thang Pham, Michael Phillips, Joy Roy, Robert Sebra, Gene Shen, Jon Sorenson, Austin Tomaney, Kevin Travers, Mark Trulson, John Vieceli, Jeffrey Wegener, Dawn Wu, Alicia Yang, Denis Zaccarin, Peter Zhao, Frank Zhong, Jonas Korlach, Stephen Turner, Real-time DNA sequencing from single polymerase molecules. Methods in Enzymology. ,vol. 472, pp. 431- 455 ,(2010) , 10.1016/S0076-6879(10)72001-2
, Prepublication data sharing Nature. ,vol. 461, pp. 168- 170 ,(2009) , 10.1038/461168A
Formulary staff, FDA approves Xalkori with companion diagnostic for a type of late-stage lung cancer Formulary ENews. ,(2011)
Rachael Natrajan, Jorge S Reis-Filho, Next-generation sequencing applied to molecular diagnostics Expert Review of Molecular Diagnostics. ,vol. 11, pp. 425- 444 ,(2011) , 10.1586/ERM.11.18
Jonathan M. Rothberg, Wolfgang Hinz, Todd M. Rearick, Jonathan Schultz, William Mileski, Mel Davey, John H. Leamon, Kim Johnson, Mark J. Milgrew, Matthew Edwards, Jeremy Hoon, Jan F. Simons, David Marran, Jason W. Myers, John F. Davidson, Annika Branting, John R. Nobile, Bernard P. Puc, David Light, Travis A. Clark, Martin Huber, Jeffrey T. Branciforte, Isaac B. Stoner, Simon E. Cawley, Michael Lyons, Yutao Fu, Nils Homer, Marina Sedova, Xin Miao, Brian Reed, Jeffrey Sabina, Erika Feierstein, Michelle Schorn, Mohammad Alanjary, Eileen Dimalanta, Devin Dressman, Rachel Kasinskas, Tanya Sokolsky, Jacqueline A. Fidanza, Eugeni Namsaraev, Kevin J. McKernan, Alan Williams, G. Thomas Roth, James Bustillo, An integrated semiconductor device enabling non-optical genome sequencing Nature. ,vol. 475, pp. 348- 352 ,(2011) , 10.1038/NATURE10242
S. A. Forbes, N. Bindal, S. Bamford, C. Cole, C. Y. Kok, D. Beare, M. Jia, R. Shepherd, K. Leung, A. Menzies, J. W. Teague, P. J. Campbell, M. R. Stratton, P. A. Futreal, COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Research. ,vol. 39, pp. 945- 950 ,(2011) , 10.1093/NAR/GKQ929
Bruce A. Chabner, Early Accelerated Approval for Highly Targeted Cancer Drugs New England Journal of Medicine. ,vol. 364, pp. 1087- 1089 ,(2011) , 10.1056/NEJMP1100548
William Lee, Zhaoshi Jiang, Jinfeng Liu, Peter M. Haverty, Yinghui Guan, Jeremy Stinson, Peng Yue, Yan Zhang, Krishna P. Pant, Deepali Bhatt, Connie Ha, Stephanie Johnson, Michael I. Kennemer, Sankar Mohan, Igor Nazarenko, Colin Watanabe, Andrew B. Sparks, David S. Shames, Robert Gentleman, Frederic J. de Sauvage, Howard Stern, Ajay Pandita, Dennis G. Ballinger, Radoje Drmanac, Zora Modrusan, Somasekar Seshagiri, Zemin Zhang, The mutation spectrum revealed by paired genome sequences from a lung cancer patient Nature. ,vol. 465, pp. 473- 477 ,(2010) , 10.1038/NATURE09004
Amy L. McGuire, Timothy Caulfield, Mildred K. Cho, Research ethics and the challenge of whole-genome sequencing Nature Reviews Genetics. ,vol. 9, pp. 152- 156 ,(2008) , 10.1038/NRG2302