Transitioning Discoveries from Cancer Genomics Research Laboratories into Pathology Practice

摘要: Genomic biomarkers are increasingly being used for detection of cancer, recognizing early disease recurrence, or to provide crucial molecular findings essential the use novel classes targeting therapies. Although there is considerable enthusiasm discoveries cancer genomics personalized medicine in clinical practice, number new incorporated into diagnosis and treatment remains surprisingly low. In this chapter we describe how laboratory approaches research usually move pathology consider why uptake genomic has been so slow. We illustrate by describing some genetic tests that successfully practice now. draw attention challenges faced delivering practice-changing discoveries; discuss potential impact on design trials. Finally, review current guidelines recommendations moving a successful biomarker from practice.