PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer

摘要: What’s known on the subject? and What does study add? So far we know that ERG rearrangements PTEN deletions interact to induce prostate cancer in transgenic mice. The confirms an association also exists between two genetic aberrations human cancer, as there is increased incidence of cases with rearrangements. OBJECTIVE To investigate interaction between, significance of, gene genomic relation development progression (PCA). PATIENTS AND METHODS We interrogated initial cohort 220 men localized PCA using fluorescence situ hybridization for deletions. RESULTS The incidences were significantly higher than high-grade prostatic intra-epithelial neoplasia (HGPIN) benign tissue (P < 0.001). detected 41.9 42.6% patients’ tumours, respectively. never tissue, while present at a basal level 4.6%. hemizygous showed frequency homozygous within each diagnostic category from HGPIN (P ≤ 0.001). Furthermore, 29 patients where all three tissues available, different those (P = 0.005) (P = 0.02), reflecting accumulation early stages disease progression. Within this cohort, 71.4% 44.2% occurred simultaneously (P ≈ 0). Stratified according Gleason score (GS), across various GS groups observed deletions. However, positive trends GS, increasing poorly differentiated (GS 8–10) comparison moderately well tumours 6 7). CONCLUSION We show significant subset PCA. Our analysis provides further support observation can occur lesions, shows accumulating progression, evidenced by detection more 8–10 6–7.