Gene expression-based diagnostics for molecular cancer classification of difficult to diagnose tumors

摘要: Introduction: Standardized methods for accurate tumor classification are of critical importance cancer diagnosis and treatment, particularly in diagnostically-challenging cases where site-directed therapies an option. Molecular diagnostics classification, subclassification site origin determination based on advances gene expression profiling have translated into clinical practice as complementary approaches to clinicopathological evaluations. Areas covered: In this review, the foundational science expression-based technical considerations translation, overview molecular signatures that available use will be discussed. Proposed also described further integration tests diagnostic paradigm using a tissue-based strategy key component direct evaluation. Expert opinion: Increasing evidence improve...