Evaluation of the kidney as a potential site of avian influenza virus persistence in chickens.

摘要: One-day-old chickens were inoculated intravenously with one of three low-pathogenicity avian-origin influenza isolates. On day 5 postinoculation (PI), the frequency virus isolation from cloacal swabs following challenge each isolate ranged 83% to 100% for clinically normal euthanatized chickens. Influenza was also frequently isolated kidneys these (47%) and that died (100%). Kidneys positive had lesions nephrosis and/or acute nephritis, viral nucleoprotein demonstrated in nuclei cytoplasm necrotic renal tubule epithelium. sampling days 28 45/60 PI, neither nor immunohistochemically (0/125); however, did have chronic histologic suggested previous infection kidneys. two 44 on but all negative recovery PI (0/81). These results indicate replication epithelial cells not result persistence type A this immunologically privileged site.