Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon.

摘要: Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild management. Here we studied genetic mechanisms driving parasite resistance in large herbivore through comprehensive approach combining measurements of neutral (16 microsatellites) adaptive (MHC DRB1 exon 2) diversity two types gastrointestinal parasites (nematodes coccidia). While accounting other extrinsic intrinsic predictors known to impact load, show that both associated with nematodes. Intermediate levels multi-locus heterozygosity maximized nematodes resistance, suggesting in- outbreeding depression might occur the population. specific alleles effects were detected, occurrence heterozygote advantage, rare-allele and/or fluctuating selection. On contrary, no association was detected between coccidia, indicating different classes impacted by drivers. This study provides important insights herbivores sheep pathogen management, particular suggests factors likely allelic frequencies, including global changes, are also expected resistance.