摘要: Abstract The formulation of ternary solid dispersions ketoprofen with Macrogol and kollagen hydrolizate derivative as carriers was elaborated on the basis results experiments in which different methods dispersion preparation (melting, solvent method, cooling), concentrations drug/carriers molecular weight were tested. best consisted of: ketoprofen–Macrogol 6000-KLH T (1+8.9+0.1) chosen to formulate pellets pharmaceutical availability from physical chemical studies: thermomicroscopic, DSC X-ray diffraction. prepared by extrusion spheronization method. mechanical properties well released containing dispersion, comparison mixtures drug alone, evaluated. increase amount 3.8-times greater than alone. stability satisfactory.
elsevier.com
sci-hub.se 参考文章(9)
E.K. Anderberg, C. Nyström, Physicochemical aspects of drug release: X. Investigation of the applicability of the cube root law for characterization of the dissolution rate of fine particulate materials International Journal of Pharmaceutics. ,vol. 62, pp. 143- 151 ,(1990) , 10.1016/0378-5173(90)90228-V
Eva Sjökvist, Christer Nyström, Maggie Aldén, Ninus Caram-Lelham, Physicochemical aspects of drug release. XIV: The effects of some ionic and non-ionic surfactants on properties of a sparingly soluble drug in solid dispersions International Journal of Pharmaceutics. ,vol. 79, pp. 123- 133 ,(1992) , 10.1016/0378-5173(92)90103-9
P. Mura, M.T. Faucci, P.L. Parrini, S. Furlanetto, S. Pinzauti, Influence of the preparation method on the physicochemical properties of ketoprofen-cyclodextrin binary systems. International Journal of Pharmaceutics. ,vol. 179, pp. 117- 128 ,(1999) , 10.1016/S0378-5173(98)00390-1
Hye Jin Ahn, Kyoung Mi Kim, Chong-Kook Kim, Enhancement of Bioavailability of Ketoprofen Using Dry Elixir as a Novel Dosage Form Drug Development and Industrial Pharmacy. ,vol. 24, pp. 697- 701 ,(1998) , 10.3109/03639049809082375
R Fekete, R Zelko, S Marton, I Racz, Effect of the formulation parameters on the characteristics of pellets Drug Development and Industrial Pharmacy. ,vol. 24, pp. 1073- 1076 ,(1998) , 10.3109/03639049809089951
María Victoria Margarit, Inés Carmen Rodríguez, Antonio Cerezo, Physical characteristics and dissolution kinetics of solid dispersions of ketoprofen and polyethylene glycol 6000 International Journal of Pharmaceutics. ,vol. 108, pp. 101- 107 ,(1994) , 10.1016/0378-5173(94)90320-4
Sang C. Chi, H.W. Jun, Release Rates of Ketoprofen from Poloxamer Gels in a Membraneless Diffusion Cell Journal of Pharmaceutical Sciences. ,vol. 80, pp. 280- 283 ,(1991) , 10.1002/JPS.2600800318
J.M. Ginés, M.J. Arias, J.R. Moyano, P.J. Sánchez-Soto, Thermal investigation of crystallization of polyethylene glycols in solid dispersions containing oxazepam International Journal of Pharmaceutics. ,vol. 143, pp. 247- 253 ,(1996) , 10.1016/S0378-5173(96)04702-3
E. Nürnberg, G. Kutz, Kollagen−Hydrolysate als pharmazeutische Hilsstoffe. II: Galenisch relevante Eigenschaften wässriger Lösungen von Kollagen−Hydrolysaten/Rheologie/Tensiometrie/Bestimmung der Molekülmassen Pharmazeutische Industrie. ,vol. 51, pp. 1037- 1040 ,(1989)