Pilot study of relative bioavailability of two oral formulations of ketoprofen 25 mg in healthy subjects. A fast-dissolving lyophilized tablet as compared to immediate release tablet.
作者： I. S. Ahmed , F. A. Fatahalla
DOI: 10.1080/03639040601150237
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摘要: ABSTRACTThe pharmacokinetics of ketoprofen from a fast-dissolving lyophilized tablet (LT), which need not be swallowed, as compared to an immediate release (IR) reference after single oral dose (25 mg) administration was determined in six healthy subjects aged between 25–40 years using randomized crossover design. In this study, the rate and extent absorption were found very different LT IR tablet. The significantly faster than that had higher Cmax (by about 50%) earlier tmax 15 min), whereas expressed by AUC 68% relative bioavailability (frel) with 168%. difference two formulations for half-life MRT statistically significant (p < 0.05). tolerance tested excellent. Ketoprofen remaine...
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