A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing

摘要: Cell proliferation and patterning must be coordinated for the development of properly proportioned organs. If same molecules were to control both processes, such coordination would ensured. Here we address this possibility in Drosophila wing using Dpp signaling pathway. Previous studies have shown that forms a gradient along AP axis patterns wing, receptors are autonomously required cell proliferation, ectopic expression either or an activated receptor, Tkv(Q253D), causes overgrowth. We extend these findings with detailed analysis effects on growth proliferation. Increasing by expressing Tkv(Q253D) accelerated cycle progression coordinate cell-autonomous manner. Conversely, inhibiting pathway specific inhibitor, Dad, mutation tkv, slowed division, also fashion. Stimulation was blocked inhibitor RBF, normal activity effector, PI3K. Among known targets, vestigial only one tested Tkv(Q253D)-induced growth. The response altering varied regionally temporally disc, indicating other patterned factors modify response.