The Role of Apoptosis in Normal and Abnormal Embryonic Development

摘要: Programmed cell death or apoptosis is a widespread biological phenomenon. Apoptosis characterized by typical features such as membrane blebbing, chromatin condensation, and DNA fragmentation. It involves number of receptors (e.g., Fas, TNFR) cascade signal transduction steps resulting in the activation cysteine proteases known caspases. Disordered may lead to carcinogenesis participates pathogenesis Alzheimer disease, Parkinson AIDS. plays an important role processes gamete maturation well embryo development, contributing appropriate formation various organs structures. one mechanisms action cytotoxic agents teratogens. Teratogen-induced excessive embryonic cells undoubtedly most events preceding occurrence structural abnormalities, regardless their nature. Therefore understanding involved physiological disturbed dysregulated development new methods preventive treatment developmental abnormalities. The present review summarizes data on programmed concentrates normal gametogenesis abnormal development.