Male breast carcinoma

作者: Ari-Nareg Meguerditchian , Ginette Martin , Maurice Falardeau

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摘要: Objective: To review the epidemiology, presentation, diagnosis, molecular genetics, treatment and prognosis of male breast cancer. Data sources: Articles, written in English or French, selected from Medline database (1966 to January 2001), corresponding key words “male cancer,” according following criteria: covering institutional experience comparing diagnostic modalities, epidemiologic general reviews. Study selection: Of 198 articles found 50 fulfilled criteria. synthesis: Risk factors included advanced age, a positive family history, Jewish origin, black race, excess exposure female hormones (Klinefelter’s syndrome), environmental (irradiation), alcohol, obesity, higher socioeconomic educational status childlessness. Gynecomastia remains controversial factor, this term being used for both histologic reality physical finding. Advanced disease is characterized by pain, bloody discharge skin ulceration. There no definitive algorithm. Experience with mammography limited, imaging less informative patients under years age. Fine-needle aspiration tends overestimate rate malignancy. The commonest finding infiltrating ductal adenocarcinoma. Treatment includes modified radical mastectomy, followed cyclophosphamide‐methotrexate‐5-fluorouracil 5-fluorouracil‐Adriamycin‐cyclophosphamide chemotherapy stage II greater. Radiotherapy does not seem add any benefit. highly receptor-positive; however, many discontinue tamoxifen due side effects. most important prognostic are tumour size, lymphatic invasion axillary node status. Conclusions: Because low incidence cancer, advances will be obtained mainly rapid transfer newly gained knowledge mammary neoplasia. increased use adjuvant combined postoperatively may have impact on survival. Public education should oriented toward men at risk reduce interval between appearance symptoms consultation. Rigorous data collection allow thorough reporting thus possibility characterizing etiology disease. Objectif : Examiner l’epidemiologie, la le diagnostic, genetique moleculaire, traitement et pronostic du cancer sein chez l’homme. Sources des donnees Des articles, en anglais ou francais, choisis dans base de janvier l’aide mots cles «male cancer», selon les criteres suivants etudes l’experience etablissement comparaison methodes epidemiologiques generales. Selection d’etudes Au nombre trouves, satisfaisaient aux d’examen. Synthese Les facteurs risque comprenaient l’âge avance, antecedents familiaux positifs, l’appartenance descendance juive race noire, l’exposition excessive feminines (syndrome Klinefelter), rayonnements l’environnement, consommation d’alcool, l’obesite, un statut socio-economique favorise niveau d’instruction eleve l’infecondite. La gynecomastie demeure facteur pretant controverse, car cette expression est utilisee pour designer tant une realite histologique qu’une constatation physique. stade ce caracterise par douleur, ecoulement sanguinolent l’ulceration cutanee.Il n’y pas d’algorithme diagnostique bien determine. L’experience mammographie l’homme limitee l’imagerie pratiquee moins ans apporte d’information. L’aspiration l’aiguille fine entraine generalement surestimation malignite. Le carcinome canalaire infiltrant plus courante. fait appel mastectomie radicale modifiee, suivie d’une chimiotherapie associant cyclophosphamide, methotrexate 5-fluoro-uracile 5-fluoro-uracile, l’Adri

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