Orphan nuclear receptor βFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal–pupal transition in Drosophila melanogaster

摘要: Abstract In Drosophila melanogaster, fluctuations in 20-hydroxyecdysone (ecdysone) titer coordinate gene expression, cell death, and morphogenesis during metamorphosis. Our previous studies have supported the hypothesis that βFTZ-F1 (an orphan nuclear receptor) provides specific genes with competence to be induced by ecdysone at appropriate time, thus directing key developmental events prepupal–pupal transition. We are examining role of morphogenesis. made a detailed study morphogenetic metamorphosis control mutant animals. show leg development mutants proceeds normally until transition, when final elongation is delayed several hours significantly reduced mutants. also fail fully extend their wings shorten bodies find unable properly perform muscle contractions drive these processes. Several defects can rescued subjecting drop pressure normal time findings indicate directs contraction major processes transition Drosophila.