MiR-629 promotes human pancreatic cancer progression by targeting FOXO3.

摘要: The FOXO signaling pathway has been reported to have an important role in human cancer. Expression of miR-629 was markedly upregulated pancreatic cancer and negatively correlated with FOXO3. Therefore, exploring the regulatory mechanism FOXO3 may provide valuable clinical targets for therapy. In current study, we found that overexpressing inhibiting miR-629, respectively, enhanced reduced cell proliferation metastasis cells vitro vivo compared parental or transfected a control vector. Furthermore, regulated protein expression decreased activity luciferase reporter construct containing 3′-untranslated region. These results show regulates at posttranscriptional level, resulting invasion carcinoma. enhanced, while reduced, stem cell-like phenotype vitro. A functional polymorphism miR-629-binding site 3′-UTR gene confers risk progression these findings suggest vital promoting development represent novel prognostic biomarker therapeutic target.