Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
作者： Ning Zhang , Yishuo Wu , Jian Gong , Kaiwen Li , Xiaolin Lin
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摘要: // Ning Zhang 1,2,* , Yishuo Wu Jian Gong 2* Kaiwen Li 3 Xiaolin Lin 2,4,5 Haitao Chen 5 Yang Yu 1,2 Yuancheng Gou Jiangang Hou Deke Jiang 4 Rong Na 1,2,6,7 Xiang Wang Qiang Ding and Jianfeng Xu 2,3,4,7 1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China 2 Institute Sun Yat-sen Memorial Yet-sen Guandong, State Key Laboratory Genetic Engineering, School Life Sciences, Center for Epidemiology, 6 Health Communication Institute, Public Health, 7 Program Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA * These authors have contributed equally to this work Correspondence to: Na, email: Wang, Keywords : renal cell carcinoma, SNPs, genome-wide association, Chinese Received June 03, 2015 Accepted December 31, Published January 14, 2016 Abstract Genome-wide association studies (GWAS) carcinoma (RCC) identified single nucleotide polymorphisms (SNPs) associated with RCC in European African American population. In study, we evaluated whether these SNPs are clear (ccRCC) All reported risk-associated from GWAS were 346 ccRCC cases 1,130 controls. Rs10054504 (at PDZD2 Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P 0.0006), rs718314 ITPR2 0.56, 95%CI:0.45-0.69, 5.26×10 -8 ) rs1049380 by dominant model, 1.58, 95%CI:1.18-2.13, 0.0025) significantly risk To conclude, genetic variations ccRCC-risk
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