Neutron vs photon irradiation of inoperable salivary gland tumors: Results of an RTOG-MRC cooperative randomized study
作者： T.W Griffin , T.F Pajak , G.E Laramore , W Duncan , M.P Richter
DOI: 10.1016/0360-3016(88)90188-5
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摘要: A total of 32 patients with inoperable, recurrent or unresectable malignant salivary gland tumors were entered on a randomized RTOG/MRC study comparing fast neutron radiotherapy conventional photon radiotherapy. Twenty-five from the United States and 7 Scotland. Seventeen to receive neutrons 15 photons. Sixty-one percent neutron-treated 75% photon-treated presented inoperable tumors, while 39% 25% had disease. study-eligible analyzable. The minimum follow-up time is 2 years. complete tumor clearance rates at primary site 85% (11/13) for 33% (4/12) photons following protocol treatment (p = 0.01). in cervical lymph nodes 86% (6/7) (1/4) overall loco/regional response respectively. control years groups are 67% 17% less than 0.005). 2-year survival 62% respectively 0.10). These findings consistent previously published uncontrolled series.
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