Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.

作者: Miklós Péterfy , Jack Phan , Ping Xu , Karen Reue

DOI: 10.1038/83685

关键词:

摘要: … of human lipodystrophy 1 , a genetically heterogeneous group of disorders characterized by … The gene (Lpin1) encodes a novel nuclear protein which we have named lipin. Consistent …

参考文章(25)
Iichiro Shimomura, Robert E. Hammer, Shinji Ikemoto, Michael S. Brown, Joseph L. Goldstein, Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature. ,vol. 401, pp. 73- 76 ,(1999) , 10.1038/43448
C.A. Langner, E.H. Birkenmeier, K.A. Roth, R.T. Bronson, J.I. Gordon, Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. Journal of Biological Chemistry. ,vol. 266, pp. 11955- 11964 ,(1991) , 10.1016/S0021-9258(18)99050-2
Jörg Hager, Christian Dina, Stephan Francke, Severine Dubois, Mouna Houari, Vincent Vatin, Emmanuel Vaillant, Nathalie Lorentz, Arnaud Basdevant, Karine Clement, Bernard Guy-Grand, Philippe Froguel, A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nature Genetics. ,vol. 20, pp. 304- 308 ,(1998) , 10.1038/3123
C A Langner, E H Birkenmeier, O Ben-Zeev, M C Schotz, H O Sweet, M T Davisson, J I Gordon, The fatty liver dystrophy (fld) mutation: A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities Journal of Biological Chemistry. ,vol. 264, pp. 7994- 8003 ,(1989) , 10.1016/S0021-9258(18)83141-6
B Senior, S S Gellis, THE SYNDROMES OF TOTAL LIPODYSTROPHY AND OF PARTIAL LIPODYSTROPHY. Pediatrics. ,vol. 33, pp. 593- 612 ,(1964)
A.K. Student, R.Y. Hsu, M.D. Lane, Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. Journal of Biological Chemistry. ,vol. 255, pp. 4745- 4750 ,(1980) , 10.1016/S0021-9258(19)85559-X
Linda C McCarthy, Jonathan Terrett, Maria E Davis, Catherine J Knights, Angela L Smith, Ricky Critcher, Karin Schmitt, Jim Hudson, Nigel K Spurr, Peter N Goodfellow, None, A First-Generation Whole Genome–Radiation Hybrid Map Spanning the Mouse Genome Genome Research. ,vol. 7, pp. 1153- 1161 ,(1997) , 10.1101/GR.7.12.1153
C. N. Rotimi, A. G. Comuzzie, W. L. Lowe, A. Luke, J. Blangero, R. S. Cooper, The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes. ,vol. 48, pp. 643- 644 ,(1999) , 10.2337/DIABETES.48.3.643
Anthony G. Comuzzie, James E. Hixson, Laura Almasy, Braxton D. Mitchell, Michael C. Mahaney, Thomas D. Dyer, Michael P. Stern, Jean W. MacCluer, John Blangero, A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 Nature Genetics. ,vol. 15, pp. 273- 276 ,(1997) , 10.1038/NG0397-273