Silver(I)-mediated oxidative C(sp3)–H amination of ethers with azole derivatives under mild conditions
作者： Xiaoyu Wu , Kai Qiao , Hong Qin , Dong Zhang , Di Gao
DOI: 10.1039/C9QO00644C
关键词:
摘要: A silver(I)-mediated oxidative N–H/C(sp3)–H coupling of NH-azoles with ethers has been developed. Various substrates were well N-alkylated in this methodology and the corresponding desired products given moderate to good yields. Moreover, late-stage alkylation bioactive molecules was achieved. This protocol involved C(sp3)–N bond formation via a radical pathway generated presence low cost readily available heptafluoroisopropyl iodide (i-C3F7I). Generally, reaction features excellent functional group compatibility, broad substrate scope, regioselectivity, fast access pharmaceuticals such as SQ 22536.
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